Динаміка показників гуморального імунітету у осіб з контамінованих територій Сумської області
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Дата
2018
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Анотація
Досліджували зміни показників гуморальної ланки системного імунітету у осіб з контамінованих територій Сумської області.
Виявили, що у 2017 році спостерігається тенденція до підвищення відносної кількості лімфоцитів на 27,3 % та 22,5 %; загального числа лімфоцитів (на 11,3 % та 21,9 % відповідно) відносно значень контрольної групи і дослідної групи у 2016 році. У мешканців територій посиленого радіоекологічного контролю Сумської області у 2017 році спостерігається: тенденція до зростання рівня концентрації Ig G відносно значень 2016 року; зниження рівня концентрації Ig M відносно контрольних значень та показників досліджуваної групи 2016 року (у 1,74 рази та 4,39 рази відповідно); зниження рівня концентрації Ig А у досліджуваній групі за вищевказаний період у 1,5 рази. У волонтерів з IV радіаційної зони Сумської області спостерігається достовірне зниження лейко–В–клітинного індексу на 27,8 %.
Таким чином, існує необхідність подальшого моніторингу показників імунної системи щодо даної категорії населення.
We researched changes in the indices of the systemic immunity humoral level in persons from contaminated territories of the Sumy region. The purpose of our study is to establish the dynamics of indicators’ changes of the humoral part of systemic immunity of individuals from contaminated territories of the Sumy region. Methods and materials. The examined were divided into two groups: residents of radiation free areas (control group, 80 persons) and the inhabitants of the areas of enhanced radiation monitoring (experimental group, 80 persons). Indicators of cellular immunity were determined by immunophenotyping and dyeing on Romanowsky–Giemsa. The level of immunoglobulins in blood plasma was determined by radial immunodiffusion on Mancini. Results and their discussion. The relative number of lymphocytes is within the clinical norm and in 2016 is close to the values of the control group. In 2017, this indicator shows a tendency to increase according to the values of both the control group and the experimental in 2016 (by 27,3 % and 22,5 %). Indicators of the total number of lymphocytes in the control and experimental group are within the clinical norm. At the same time, in 2017 in the research group there is a tendency to increase this indicator according to the values of both the control group and the experimental in 2016 (by 11,3 % and 21,9 %). We established that the inhabitants of the territory of the intensified radioecological control of the Sumy region in 2017 observed: a tendency to increase the concentration of Ig G relative to the similar values of 2016; a decrease in the concentration of Ig M relative to the control values and indices of the study group in 2016 (1,74 times and 4,39 times respectively); decrease in the concentration of Ig A in the study group during the above period in 1,5 times. Volunteers from the IV radiation zone of the Sumy region have a significant decrease in the leuko-B cell index by 27,8 %. Conclusions. Thus, by investigating the indicators’dynamic of humoral immunity of individuals in the contaminated territories of the Sumy region (density of soils contamination by isotopes of cesium-137 from 1 to 5 Ki / km2), results have been obtained indicating the functional load of this link (due to the tendency to increase absolute number of B-lymphocytes (CD22)). At the same time, there is a certain dynamics of the absolute and relative number of major classes of immune cells, as well as changes in the levels of serum immunoglobulins of classes A and M (may indicate the presence of compensatory mechanisms in response to chronic irradiation). Prospects for further research. The obtained results point to the necessity of studying the compensatory mechanisms of the immune system and their potential in providing an effective integrative activity of the human body. At the same time, they indicate the need for immunological surveys for the population in the territories of the intensified radioecological control of our state (and in particular, in Sumy region) with the aim of developing and applying immunorehabilitation measures for this category of population.
We researched changes in the indices of the systemic immunity humoral level in persons from contaminated territories of the Sumy region. The purpose of our study is to establish the dynamics of indicators’ changes of the humoral part of systemic immunity of individuals from contaminated territories of the Sumy region. Methods and materials. The examined were divided into two groups: residents of radiation free areas (control group, 80 persons) and the inhabitants of the areas of enhanced radiation monitoring (experimental group, 80 persons). Indicators of cellular immunity were determined by immunophenotyping and dyeing on Romanowsky–Giemsa. The level of immunoglobulins in blood plasma was determined by radial immunodiffusion on Mancini. Results and their discussion. The relative number of lymphocytes is within the clinical norm and in 2016 is close to the values of the control group. In 2017, this indicator shows a tendency to increase according to the values of both the control group and the experimental in 2016 (by 27,3 % and 22,5 %). Indicators of the total number of lymphocytes in the control and experimental group are within the clinical norm. At the same time, in 2017 in the research group there is a tendency to increase this indicator according to the values of both the control group and the experimental in 2016 (by 11,3 % and 21,9 %). We established that the inhabitants of the territory of the intensified radioecological control of the Sumy region in 2017 observed: a tendency to increase the concentration of Ig G relative to the similar values of 2016; a decrease in the concentration of Ig M relative to the control values and indices of the study group in 2016 (1,74 times and 4,39 times respectively); decrease in the concentration of Ig A in the study group during the above period in 1,5 times. Volunteers from the IV radiation zone of the Sumy region have a significant decrease in the leuko-B cell index by 27,8 %. Conclusions. Thus, by investigating the indicators’dynamic of humoral immunity of individuals in the contaminated territories of the Sumy region (density of soils contamination by isotopes of cesium-137 from 1 to 5 Ki / km2), results have been obtained indicating the functional load of this link (due to the tendency to increase absolute number of B-lymphocytes (CD22)). At the same time, there is a certain dynamics of the absolute and relative number of major classes of immune cells, as well as changes in the levels of serum immunoglobulins of classes A and M (may indicate the presence of compensatory mechanisms in response to chronic irradiation). Prospects for further research. The obtained results point to the necessity of studying the compensatory mechanisms of the immune system and their potential in providing an effective integrative activity of the human body. At the same time, they indicate the need for immunological surveys for the population in the territories of the intensified radioecological control of our state (and in particular, in Sumy region) with the aim of developing and applying immunorehabilitation measures for this category of population.
Опис
Ключові слова
імунна система, immune system, гуморальна ланка, humoral part, територія посиленого радіоекологічного контролю, low intensity prolonged radiation, низькоінтенсивне пролонговане випромінювання, territory of the intensified radioecological control
Бібліографічний опис
Білокур, Д. О. Динаміка показників гуморального імунітету у осіб з контамінованих територій Сумської області [Текст] / Д. О. Білокур, В. І. Шейко, О. С. Львов // Вісник проблем біології і медицини. – 2018. – Випуск 3 (145). – С. 59–62.