Стан показників гуморальної ланки системного імунітету у осіб з територій посиленого радіоекологічного контролю Сумської області
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Дата
2018
Назва журналу
Номер ISSN
Назва тому
Видавець
Чорноморський національний університет ім. Петра Могили (м. Миколаїв)
Анотація
Вивчали показники гуморального імунітету у осіб з територій посиленого радіоекологічного контролю Сумської області.
Імунологічне обстеження проведено у 160 осіб віком 18-35 років, які були об’єднані у контрольну (80 осіб) і дослідну (80 осіб) групи. Було застосовано загальноприйняті методики дослідження показників імунітету. Здійснено статистичну обробку даних. Дослідження виконано у відповідності до біоетичних норм з дотриманням законодавства України.
Виявили, що у мешканців IV радіаційної зони Сумської області формується набутий імунодефіцитний стан за рівнем продукції імуноглобулінів класів G та М.
Водночас, спостерігається формування компенсаторних механізмів у відповідь на низькоінтенсивне пролонговане радіаційне опромінювання, про що свідчить зростання індексу імунної резистентності.
The state of humoral immunity in individuals from the territories of the intensified radioecological control of Sumy region is under investigation. Contamination of large areas with radionuclides due to the Chernobyl accident is considered to be an immunosuppressive factor for the population of Ukraine. The purpose of this research is to determine the іndicators of humoral immunity of individuals in the territories of intensified radioecological control of the Sumy region. Methods and materials. The examined were divided into two groups: residents of radiation free areas (control group, 80 persons) and the inhabitants of the areas of enhanced radiation monitoring (experimental group, 80 persons). Indicators of cellular immunity were determined by immunophenotyping and dyeing on Romanowsky-Giemsa. The level of immunoglobulins in blood plasma was determined by radial immunodiffusion on Mancini. Results and their discussion. We have found that examined from radiation free areas have quite stable humoral indices that don't go beyond homeostatic norm. The absolute and relative number of B-lymphocytes with the CD22 phenotype in persons from contaminated territories of Sumy region was 21% and 9% higher than the control indicators. In our opinion, an increase in the absolute number of B-lymphocytes (CD22) is a compensatory response to a decrease in the total level of leukocytes. According to literary sources, an increase in the relative number of B-lymphocytes compensates for some immunosuppression of the T-cell immunity. In residents of territories contaminated with radionuclides, there can be observed a redistribution of indices of specific immunity in favor of increase of serum immunoglobulin IgM and lowering the level of immunoglobulin’s concentration on the background of the absence of strongly pronounced dynamics of antibody-forming cells. Conclusion. The obtained results indicate the functional load of the humoral part of systemic immune system among the population of radiation-polluted territories of the Sumy region. At the same time, the formation of compensatory mechanisms in response to low-intensity prolonged radiation irradiation is observed. Prospects for further research. The obtained results indicate the necessity of carrying out immunological surveys among the population of intensified radioecological control of our state (and in particular of Sumy region) in order to carry out immunorehabilitation measures for this category of population.
The state of humoral immunity in individuals from the territories of the intensified radioecological control of Sumy region is under investigation. Contamination of large areas with radionuclides due to the Chernobyl accident is considered to be an immunosuppressive factor for the population of Ukraine. The purpose of this research is to determine the іndicators of humoral immunity of individuals in the territories of intensified radioecological control of the Sumy region. Methods and materials. The examined were divided into two groups: residents of radiation free areas (control group, 80 persons) and the inhabitants of the areas of enhanced radiation monitoring (experimental group, 80 persons). Indicators of cellular immunity were determined by immunophenotyping and dyeing on Romanowsky-Giemsa. The level of immunoglobulins in blood plasma was determined by radial immunodiffusion on Mancini. Results and their discussion. We have found that examined from radiation free areas have quite stable humoral indices that don't go beyond homeostatic norm. The absolute and relative number of B-lymphocytes with the CD22 phenotype in persons from contaminated territories of Sumy region was 21% and 9% higher than the control indicators. In our opinion, an increase in the absolute number of B-lymphocytes (CD22) is a compensatory response to a decrease in the total level of leukocytes. According to literary sources, an increase in the relative number of B-lymphocytes compensates for some immunosuppression of the T-cell immunity. In residents of territories contaminated with radionuclides, there can be observed a redistribution of indices of specific immunity in favor of increase of serum immunoglobulin IgM and lowering the level of immunoglobulin’s concentration on the background of the absence of strongly pronounced dynamics of antibody-forming cells. Conclusion. The obtained results indicate the functional load of the humoral part of systemic immune system among the population of radiation-polluted territories of the Sumy region. At the same time, the formation of compensatory mechanisms in response to low-intensity prolonged radiation irradiation is observed. Prospects for further research. The obtained results indicate the necessity of carrying out immunological surveys among the population of intensified radioecological control of our state (and in particular of Sumy region) in order to carry out immunorehabilitation measures for this category of population.
Опис
Стаття
Ключові слова
імунна система, immune system, гуморальний імунітет, humoral immunityterritory., іонізуюче випромінювання, ionizing radiation, територія посиленого радіоекологічного контролю, territory of the intensified radioecological control
Бібліографічний опис
Білокур, Д. О. Стан показників гуморальної ланки системного імунітету у осіб з територій посиленого радіоекологічного контролю Сумської області / Д. О. Білокур // Український журнал медицини, біології та спорту. – 2018. – Т. 4. – С. 184–187.